Adenosine Prompts the Heart to Recruit Endothelial Progenitors
نویسندگان
چکیده
منابع مشابه
Adenosine prompts the heart to recruit endothelial progenitors.
Adenosine has a long history of involvement in cardiac function. It was first purified from mammalian heart homogenates in 1929 by Drury and Szent-Györgyi,1 who reported a “suppressive” action of adenosine on the heart, including decreased heart beat rate and perfusion pressure,1 now termed bradycardia and coronary artery vasodilation, respectively. Based on a variety of experimental results fr...
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Intracoronary delivery of endothelial progenitor cells (EPCs) is an emerging concept for the treatment of cardiovascular disease. Enhancement of EPC adhesion to vascular endothelium could improve cell retention within targeted organs. Because extracellular adenosine is elevated at sites of ischemia and stimulates neovascularization, we examined the potential role of adenosine in augmenting EPC ...
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The embryonic heart is composed of two cell layers: the myocardium, which contributes to cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart. Whereas significant progress has been made toward elucidating the embryonic origins of the myocardium, the origins of the endocardium remain unclear. Here, we have identified an endocardium-forming field medial to the car...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2008
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.170522